Centrophenoxine (meclofenoxate, Lucidril) - Stop your brain from rotting away

  • used to improve memory and general cognition in people with dementia (including dementia induced by Alzheimer's disease)
    • there is currently no cure for dementia (boo!), but a number of drugs are available to slow its progression (half-hearted yay!)
  • also has been shown to be useful for treating cerebral atrophy (i.e. your brain rotting away) as well as brain injury due to trauma, chronic alcoholism (e.g. W-K syndrome), and aluminum and barbiturate intoxication (poisoning)
  • consists of dimethylaminoethanol (DMAE) joined by an ester linkage to parachlorophenoxyacetate (pCPA)
    • DMAE is a natural compound found in things including fish and the human brain that is converted by the brain into acetylcholine, a neurotransmitter that is thought to have roles in memory and cognition
    • DMAE is also able to scavenge (detoxify) free radicals, which can potentially help to reduce brain damage following injury
    • pCPA is a synthetic compound that structurally resembles plant hormones called auxins and, being relatively lipid-lovin', is thought to improve the ability of the drug to cross the blood-brain barrier and get into the brain
  • has been shown to stimulate brain metabolism, increase the lifespan of lab animals (antiaging effects) and improve learning capacity (nootropic effects)
Nehru B, Bhalla P, Garg A. Evidence for centrophenoxine as a protective drug in aluminium induced behavioral and biochemical alteration in rat brain. Mol Cell Biochem. 2006 Oct;290(1-2):33-42. Epub 2006 Sep 13.

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