Alpha-Methyltryptamine (AMT) - Russian antidepressant turned American hallucinogen

  • synthetic tryptamine monoamine oxidase inhibitor invented by the Soviets (they called it Indopan) in the 1960s to treat people with depression

  • in addition to alleviating depression, it does other exciting things that have lead to its recreational use:
  • was essentially legal in the USA and available for purchase online prior to April 2003, at which point the DEA had it designated a Schedule 1 controlled substance because a college student died while on it
  • like psilocybin and DMT, acts at serotonin receptors (specifically, the 5-HT2 subtype) in the brain and disrupts serotonin breakdown (since it inhibits monoamine oxidase)
  • also called IT-290 and 3-IT
  • is closely related to alpha-ethyltryptamine (also called etryptamine, α-ethyltryptamine, α-ET, AET, and Monase), which has an ethyl group in place of a methyl group, and interestingly was initially developed in the USA as an antidepressant!
- Boland DM, Andollo W, Hime GW, Hearn WL. Fatality due to acute alpha-methyltryptamine intoxication. J Anal Toxicol. 2005 Jul-Aug;29(5):394-7.
- http://en.wikipedia.org/wiki/Alphamethyltryptamine
- http://en.wikipedia.org/wiki/Alpha-ethyltryptamine

2 chemically inspired comments:

Scotto said...

Don't forget that when they were studying IT-290 for possible use as an antidepressant (har), one of the side effects was listed as "inappropriate smiling".

Anonymous said...

Funny side effects are the best.