Griseofulvin - For extra tough ringworm
- mycotoxin produced by various members of the fungal genus Penicillium, including it's namesake, Penicillium griseofulvum
- binds to microtubules and disrupts fungal cell mitosis, also inhibits nucleic acid synthesis
- net effect: prevents the fungus from growing, allowing the immune system to kick some tail
- the first oral drug developed for the treatment of ringworm
- usually indicated for use when topical treatments for ringworm fail to do anything
- ringworm is a freakin' misnomer, it's actually a related group of fungi called dermatophytes that are able to infect the skin, hair, and nails of people and some animals
- dermatophytes belong to the genera Microsporum, Trichophyton, and Epidermophyton and are geophilic, zoophilic, or anthropophilic (live in soil, animals, or humans)
- ringworm infections are usually confined to the superficial layers of the skin
- ringworm is also referred to as tinea X, where X =
- barbae - bearded areas of the face and neck
- capitis - scalp and hair
- corporis - trunk, legs, and arms
- cruris - groin (jock itch)
- pedis - feet (athlete's foot)
- manuum - hands
- unguium - fingernails or toenails
- is able to somehow preferentially accumulate in the keratinous layer of the epidermis (the upper layers of the skin), making it really good at attacking ringworm
- development timeline:
- 1939 - first isolated from a culture of Penicillium griseofulvum
- 1955 - discovered to be very active in vitro (i.e. on a lab bench) against pathogenic skin fungi, but topical ointments were not found to be any better than existing ones
- 1958 - publication of a report on the successful treatment of experimental fungus infections in guinea pigs by oral administration of griseofulvin, first used successfully in humans
- suboxone is a detox drug that can be used to treat opiate addiction
- if you are addicted to painkillers and want to get better, suboxone detox is available at a suboxone treatment center
- http://en.wikipedia.org/wiki/Griseofulvin
4 chemically inspired comments:
Griseofulvin is a preferred agent for inducing irreversible porphyria in lab animals. Dad one of my highschool classmates was doing porphyria research. The net effect of proto-porhyrin accumulation in organs was that the mice organs became UV-fluorescent. These were very sick animals indeed.
I would think twice before treating my skin ifection by systemic administration of something with such a profound liver tox. Especially now when we have Fluconazole and Terbinafine.
good info
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We studied a nice synthesis of griseofulvin by Gilbert Stork in JACS in grad school.
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