Aspirin: The keep 'em in the kitchen drug

An analysis of data from clinical trials evaluating the effect of aspirin on preventing heart attacks suggests that the drug has sexist tendencies. Science be rocking the discrimination lately, eh?

Apparently aspirin is less effective at preventing non-fatal heart attacks in women relative to men. It has been suggested that this gender difference reflects a greater prevalence of aspirin resistance in women. Aspirin resistance refers to the reduced ability of aspirin to thin the blood (i.e. prevent the aggregation of platelets, which can lead to blood clot formation) in some unlucky people.

The less effective in the ladies thing might also have something to do with the fact that women who develop heart disease are typically older and have progressed further along with the disease at the time of diagnosis. The coronary vessels (the blood vessels that supply the heart muscle) are typically smaller in women compared to men, which might also have something to do with it.

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1 chemically inspired comments:

Anonymous said...

Reminds me of the opioid analgesic sex differences controversy.