Galanthamine (Razadyne, Reminyl, Nivalin)

  • reversible competitive inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholinergic receptors
    • enhances brain function by increasing the amount of acetylcholine, a chemical substance required for the function of certain neural pathways, in the brain
  • used to treat mild to moderate Alzheimer's disease
  • found in several members of the Amaryllidaceae, a family of flowering plants that grow from bulbs and often produce nice-looking flowers (e.g. common snowdrop, one of the first flowers to bloom in the spring)
  • originally used to treat poliomyelitis (polio), myasthenia gravis (a disease featuring progressive fatigue and muscle weakness), and muscular dystrophy in Eastern Europe during the Cold War
Heinrich M, Lee Teoh H. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92(2-3):147-62.

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