tag:blogger.com,1999:blog-37623912.post-23849886046056367182007-08-11T14:20:00.001-04:002008-03-21T12:45:30.913-04:002008-03-21T12:45:30.913-04:00<ul><li>quaternary <a href="http://cancerweb.ncl.ac.uk/cgi-bin/omd?phenanthridine">benzophenanthridine</a> <a href="http://en.wikipedia.org/wiki/Glycoside">glycoside</a> alkaloid synthesized by plants belonging to the <a href="http://www.botany.hawaii.edu/Faculty/Carr/papaver.htm"><span style="font-style: italic;">Papaveraceae</span></a>, <a href="http://en.wikipedia.org/wiki/Fumariaceae"><span style="font-style: italic;">Fumariaceae</span></a>, and <a href="http://www.botany.hawaii.edu/Faculty/Carr/rut.htm"><span style="font-style: italic;">Rutaceae</span></a> families</li><ul><li>quaternary compounds possess a permanent positive charge, making them exceedingly lousy at passing through fatty things like cell membranes</li><li>specific plants include <a href="http://en.wikipedia.org/wiki/Bloodroot"><span style="font-style: italic;">Sanguinaria canadensis</span></a> (Bloodroot), <a href="http://en.wikipedia.org/wiki/Greater_celandine"><span style="font-style: italic;">Chelidonium majus</span></a> (Greater celandine), and <a href="http://en.wikipedia.org/wiki/Argemone_mexicana"><span style="font-style: italic;">Argemone mexicana</span></a> (Mexican prickly poppy)</li></ul><li>the seeds of <span style="font-style: italic;">Argemone mexicana</span> look very much like mustard seeds, which can (and <a href="http://www.ajcn.org/cgi/content/abstract/28/8/883">has</a>) lead to the <a href="http://www.itg.be/itg/DistanceLearning/LectureNotesVandenEndenE/47_Medical_problems_caused_by_plantsp8.htm">adulteration</a> of foods cooked using mustard oil with sanguinarine</li><ul><li>people consuming said foods this thing called <a href="http://en.wikipedia.org/wiki/Epidemic_dropsy">epidemic dropsy</a>, which features such exciting symptoms as your limbs swelling up (extremity swelling with pitting edema), anemia, heart failure, renal failure, and glaucoma</li></ul><li>found in some mouthwashes and toothpastes since it kills bacteria (helping to reduce <a href="http://en.wikipedia.org/wiki/Dental_caries">dental caries</a>) and has antiinflammatory effects (apparently helping to reduce gingivitis)</li><ul><li>Viadent, a toothpaste/mouthwash brand that contains sanguinarine, has been linked to oral <a href="http://www.mayoclinic.com/health/leukoplakia/DS00458">leukoplakia</a></li></ul><li>has been shown to induce <a href="http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Apoptosis.html">apoptosis</a> in certain cancer cell lines, possibly related to its ability to inhibit the activation of nuclear transcription factor NF-kB (which is involved in regulating cell growth and apoptosis and stuff) or promote the production of reactive oxygen species and/or mitochondrial membrane depolarization</li><li>it's worth considering the purchase of <a href="http://www.druglibrary.org/library/drugs.html">drugs online</a>, since it's easy and inexpensive, and there is lots of <a href="http://www.goaskalice.columbia.edu/Cat2.html">information</a> available to inform you</li><li>whether it's <a href="http://www.druglibrary.org/library/diet-drugs.html">diet drugs</a> or <a href="http://www.druglibrary.org/library/viagra.html">cheap Viagra</a>, which happens to have <a href="http://www.health.harvard.edu/press_releases/viagra-and-pulmonary-hypertension.htm">more uses</a> than you might think, they can be found on the Internet<br /></li></ul><span style="font-size:85%;">- Allen CL, Loudon J, Mascarenhas AK. Sanguinaria-related leukoplakia: epidemiologic and clinicopathologic features of a recently described entity. Gen Dent. 2001 Nov-Dec;49(6):608-14.<br />- Chang MC et al. Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization. Toxicol Appl Pharmacol. 2007 Jan 15;218(2):143-51. Epub 2006 Nov 1.</span>Chrishttp://www.blogger.com/profile/05349466286549537039[email protected]