tag:blogger.com,1999:blog-37623912.post8987273772176664630..comments2012-03-28T17:23:12.219-04:00Chrishttp://www.blogger.com/profile/05349466286549537039[email protected]Blogger6125tag:blogger.com,1999:blog-37623912.post-11405669055545112662009-06-03T17:51:34.789-04:002009-06-03T17:51:34.789-04:00Most antidepressants are not very good drugs. In many cases a low dose of hormone replacement therapy, i.e. testosterone for men over 30, or even a low dose opiate like tylenol #3 is far superiour to trying to directly fool around with the neurotransmitters. As an organic chemist I am never surprised at the potentially dangerous drugs the FDA will approve, while safer drugs remain illegal. Its a shame more chemists can think beyond molecules and money.Anonymous[email protected]tag:blogger.com,1999:blog-37623912.post-32185162896533245192007-06-11T00:35:00.000-04:002007-06-11T00:35:00.000-04:00I like the blog, great work.<BR/><BR/>julian: I don't know the details, but reboxetine inhibits an enzyme and atomoxetine blocks a channel. I would think that anything that blocks an enzymatic function might show an effect at a lower dose than something that's blocking channels (i.e. you would need more of a drug to stop an effect that utilizes many channels as opposed to stopping an effect that requires blocking a few enzymes).<BR/><BR/>also, there are probably some clearance and half-life differences, but I'm too lazy to look it up right now.Ryanhttp://www.blogger.com/profile/09229048051639753761[email protected]tag:blogger.com,1999:blog-37623912.post-70190531740268724652007-05-12T19:32:00.000-04:002007-05-12T19:32:00.000-04:00There's also reboxetine and atomoxetine as (IIRC, reasonably selective) NRI's. Although having said that, atomoxetine isn't really an AD, even though I've read that it was originally intended to be one, and has instead been marketed as a non-stimulant medication for ADHD.<BR/><BR/>Besides the fact they're usually being used for different things, any idea as to the disparity in their average/starting dosages?Julian[email protected]tag:blogger.com,1999:blog-37623912.post-8490472713020082162007-05-12T17:17:00.000-04:002007-05-12T17:17:00.000-04:00anonymous is correct. Bupropion is technically a second-generation antidepressant, developed just prior to the SSRIs. I'm gonna do a post on it sometime, as it's pretty darn neat.CNDhttp://www.blogger.com/profile/05349466286549537039[email protected]tag:blogger.com,1999:blog-37623912.post-54017639808540294482007-05-12T13:37:00.000-04:002007-05-12T13:37:00.000-04:00It's a norepinephrine-dopamine reuptake inhibitor.<BR/><BR/>There's also a recent class of serotonin-norepinephrine reuptake inhibitors, SNRIs.Anonymous[email protected]tag:blogger.com,1999:blog-37623912.post-58791761292606499052007-05-11T22:17:00.000-04:002007-05-11T22:17:00.000-04:00Where does Wellbutrin (buproprion) fit in? It's not an SSRI, and the sexually-related side effects are actually kind of cool.Larryhttp://www.blogger.com/profile/05234072020943082331[email protected]