tag:blogger.com,1999:blog-37623912.post4034135965872985116..comments2007-10-10T03:45:54.614-04:00Comments on Drugs and Poisons: Another COX-2 inhibitor bites the dustChrishttp://www.blogger.com/profile/05349466286549537039[email protected]Blogger1125tag:blogger.com,1999:blog-37623912.post-33298330723220372132007-10-10T03:45:00.000-04:002007-10-10T03:45:00.000-04:00Well, different to vioxx but not tooo different to...Well, different to vioxx but not tooo different to diclofenac it's ancestor - which also has a history of idiosyncratic liver toxicity ascribed to glucuronide conjugation of the hydroxylated form. OK, so the methyl is there to block the obvious site of oxidation but what if it happens on the other ring? <BR/>Cynics would also disagree with the 'selective' COX2 tag - those assays are very sensitive to how you run them and a company with an existing NSAID franchise wouldn't want to miss the new marketing boat now would they?DrSnowboard[email protected]