Comments on Drugs and Poisons: Mitragynine - Speedballing for lazy people

"Unfortunately, the accessibility of the drie...

2010-08-26T00:56:33.681-04:00

"Unfortunately, the accessibility of the dried leaf (and fortified extracts) on the itnernet is creating an army of addicts. Like any mu opioid agonist, 7-hydroxymitragynine (and mitragynine) are extremely addictive! Painful, horrible withdrawal, escalating doses, etc..."

Wrong, wrong and wrong. Compared to the more powerful opiate painkillers, the number of people addicted to mitragynine is extremely low. This substance is much less addictive than opiates, and the withdrawal syndrome, by all accounts, is much less severe. Please do your homework before posting.

Many of these legal highs contain analogues of con...

2008-08-13T02:58:00.000-04:00

Many of these legal highs contain analogues of controlled substances. No proper clinical testing has been done and we have only anecdotal reports to go on. The biggest danger lies not with the herbs (since some of these have had a long history of indigenous use) but with the so called "Party Pills" and herbal ecstasy pills that contain anything from methamphetamine analogues to aporphine alkaloids like Glaucine. Not to mention that the manufacturers of these products make it a point to NOT reveal the ingredients of their pills let alone the quantity of the ingredients. I can agree how the use of such products could serve a purpose in Harm Reduction, but the very fact that the manufacturers do not reveal the contents of what they sell, poses a terrible risk to the consumer.

I don't quite agree with the second comment made. ...

2008-08-11T02:45:00.000-04:00

I don't quite agree with the second comment made. Mitragynin and 7-OH are not terribly addictive. Whilst 7-OH is more potent than Morphine (probably on par with hydromorphone), the administration of the whole plant reduces the overall addictive potential due to the other alkaloids present, one of which acts as a partial mu-agonist, another as a full antagonist at mu and yet another as an NMDA-antagonist. Additionally, withdrawal symptoms have been described as being milder than that of morphine, and shorter in duration. Whilst tachyphylaxis is expected of most mu-agonists, 7-OH-mitragynine is selective for mu-1, not mu-2.
Good article by the way. I enjoyed reading your blog :)

Plenty of "legal highs" out there (plants in the g...

2008-07-08T05:37:00.000-04:00

Plenty of "legal highs" out there (plants in the garden, research chemicals, plant extractions, inhailants), but I would like to see more scientific research before I ever concidered experimented. SO far anything proven to make you feel good is illegal or controlled by the governement.

FYI this really is a no-joke opiod, from the persp...

2008-04-23T16:14:00.000-04:00

FYI this really is a no-joke opiod, from the perspective of dose escalation and withdrawals. I didn't treat it as the real deal, and I paid dearly in terrible terrible withdrawal that lasted for close to 2 weeks. Be mighty careful with this one!

I'm always looking to try new experiments with eth...

2007-12-14T14:28:00.000-05:00

I'm always looking to try new experiments with ethnobotanicals. I have been researching forever and cannot find info on hoe to synthesize 7-OH from mitragynine. any help please =)

I'm glad you posted on this plant and its drugs. ...

2007-07-31T18:39:00.000-04:00

I'm glad you posted on this plant and its drugs. Fascinating. Unfortunately, the accessibility of the dried leaf (and fortified extracts) on the itnernet is creating an army of addicts. Like any mu opioid agonist, 7-hydroxymitragynine (and mitragynine) are extremely addictive! Painful, horrible withdrawal, escalating doses, etc...

the fact that you included the words "erectile dys...

2007-07-18T15:05:00.000-04:00

the fact that you included the words "erectile dysfuntion" will probably get you a bajillion hits from google. Not that you don't already have that problem, judging from your Google search posts, but funny anyways.